Primary Sclerosing Cholangitis, Crohn's disease and HLA-B27 in Black South African Women
| Journal | Volume 75 - 2012 |
| Issue | Fasc.4 - Case reports |
| Author(s) | O.C. Buchel, F.J. Bosch, J. Janse van Rensburg, E. Bezuidenhout, C.S. de Vries, J.H. van Zyl, B.D. Middlecote, H. de K Grundling, J. Fevery |
| Full article |
 VIEW FREE PDF |
| Departments of (1) General Surgery, (2) Gastroenterology, (3) Radiology, (4) Anatomical Pathology, Universitas Academic Hospital, University of the Free State, Bloemfontein, South Africa and (5) Hepatology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium. |
|
Crohn's disease is rare in South African black people and primary sclerosing cholangitis (PSC) is also rare in black patients with IBD, from South Africa. The presence of HLA-B27 is generally associated with seronegative spondylo-arthropathies and correlates with the occurrence of ankylosing spondylitis, recurrent mouth ulcers and uveitis, in patients with IBD. We describe two women with the combination of Crohn's disease, PSC and HLA- B27 from our cohort of the last 5 years of three black patients with Crohn's disease. Crohn's disease, PSC and HLA-B27 respectively, occur rarely in black South Africans and their concurrent presence in two black women suggests a pathogenetic link of HLA-B27 between Crohn's disease and PSC in this population. Female gender might be an additional determinant in this setting. (Acta gastroenterol. belg., 2012, 75, 454-457). |
|
© Acta Gastro-Enterologica Belgica. PMID 23402092 |
